BIRC3 Antibody

• Background:

  The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq].

• NCBI Gene ID:

  330

• Swiss Prot:

  Q13489

• Accession Number:

  Q13489

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BIRC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the N-terminal region of human BIRC3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  68 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BIRC3

• NCBI Official Name:

  Baculoviral IAP repeat-containing protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zane, L., et al. Virology 407 (2) :341-351 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Kim, C.W., et al. Biochem. Biophys. Res. Commun. 400 (1) :46-52 (2010)

• Background Reference 04:

  Petersen, S.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (26) :11936-11941 (2010)

• Other Product Names:

  Baculoviral IAP repeat-containing protein 3, 632-, Apoptosis inhibitor 2, API2, C-IAP2, IAP homolog C, Inhibitor of apoptosis protein 1, IAP-1, hIAP-1, hIAP1, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1, BIRC3, API2, IAP1, MIHC, RNF49

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  2497236

• Physical Properties:

  Liquid