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UGT1A1 Antibody

CAT: 0223-57-373Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-373Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
NCBI Gene ID
54658
Swiss Prot
P22309
Accession Number
P22309
Host
Rabbit
Reactivity
Human
Immunogen
This UGT1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-90 amino acids from the N-terminal region of human UGT1A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
UGT1A1
NCBI Official Name
UDP-glucuronosyltransferase 1-1
NCBI Organism
Homo sapiens
Background Reference 01
Italia, K.Y., et al. Clin. Biochem. 43 (16-17), 1329-1332 (2010) :
Background Reference 02
Justenhoven, C., et al. Breast Cancer Res. Treat. 124 (1) :289-292 (2010)
Background Reference 03
Hu, M., et al. Pharmacogenet. Genomics 20 (10) :634-637 (2010)
Background Reference 04
Sai, K., et al. BrClin Pharmacol 70 (2) :222-233 (2010)
Other Product Names
UDP-glucuronosyltransferase 1-1, UDPGT 1-1, UGT1*1, UGT1-01, UGT11, Bilirubin-specific UDPGT isozyme 1, hUG-BR1, UDP-glucuronosyltransferase 1-A, UGT-1A, UGT1A, UDP-glucuronosyltransferase 1A1, UGT1A1, GNT1, UGT1
Tested Applications
WB, IHC-P, IF
Protein ID
136729
Physical Properties
Liquid

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