RARA Antibody

• Background:

  This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.

• NCBI Gene ID:

  5914

• Swiss Prot:

  P10276

• Accession Number:

  P10276

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 amino acids from the C-terminal region of human RARA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RARA

• NCBI Official Name:

  Retinoic acid receptor alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Park, U.H., et al. J. Biol. Chem. 285 (44) :34269-34278 (2010)

• Background Reference 02:

  Asleson, A.D., et al. Cancer Genet. Cytogenet. 202 (1) :33-37 (2010)

• Background Reference 03:

  Catalano, A., et al. Blood 110 (12) :4073-4076 (2007)

• Background Reference 04:

  Wells, R.A., et al. Nat. Genet. 17 (1) :109-113 (1997)

• Other Product Names:

  Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, RARA, NR1B1

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  133483

• Physical Properties:

  Liquid