IL13 Antibody

• Background:

  This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].

• NCBI Gene ID:

  3596

• Swiss Prot:

  P35225

• Accession Number:

  P35225

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human IL13.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  16 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IL13

• NCBI Official Name:

  Interleukin-13

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Shi, X., et al. Anat Rec (Hoboken) 293 (9) :1470-1476 (2010)

• Background Reference 03:

  Beckers, M.M., et al. Eur. J. Intern. Med. 21 (4) :289-292 (2010)

• Background Reference 04:

  Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :

• Other Product Names:

  Interleukin-13, IL-13, IL13, NC30

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  239938644

• Physical Properties:

  Liquid