LGALS3 Antibody

• Background:

  This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  3958

• Swiss Prot:

  P17931

• Accession Number:

  P17931

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This LGALS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the C-terminal region of human LGALS3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  LGALS3

• NCBI Official Name:

  Galectin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Salomonsson, E., et al. J. Biol. Chem. 285 (45) :35079-35091 (2010)

• Background Reference 02:

  Debierre-Grockiego, F., et al. J. Biol. Chem. 285 (43) :32744-32750 (2010)

• Background Reference 03:

  Zhou, J.Y., et al. J. Proteome Res. 9 (10) :5133-5141 (2010)

• Background Reference 04:

  Markowska, A.I., et al. J. Exp. Med. 207 (9) :1981-1993 (2010)

• Other Product Names:

  Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, LGALS3, MAC2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  215274262

• Physical Properties:

  Liquid