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TLR7 Antibody

CAT: 0223-57-215Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-215Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
NCBI Gene ID
51284
Swiss Prot
Q9NYK1
Accession Number
Q9NYK1
Host
Rabbit
Reactivity
Human
Immunogen
This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-926 amino acids from the C-terminal region of human TLR7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
121 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TLR7
NCBI Official Name
Toll-like receptor 7
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Manuse, M.J., et al. Virology 405 (2) :383-389 (2010)
Background Reference 03
Cros, J., et al. Immunity 33 (3) :375-386 (2010)
Background Reference 04
Shen, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (36) :15838-15843 (2010)
Other Product Names
Toll-like receptor 7, TLR7
Tested Applications
WB
Protein ID
20140876
Physical Properties
Liquid

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