CORO2A Antibody

• Background:

  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants.

• NCBI Gene ID:

  7464

• Swiss Prot:

  Q92828

• Accession Number:

  Q92828

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CORO2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human CORO2A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CORO2A

• NCBI Official Name:

  Coronin-2A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jin, Y., et al. Nat. Genet. 42 (7) :576-578 (2010)

• Background Reference 02:

  Marshall, T.W., et al. J. Cell. Sci. 122 (PT 17), 3061-3069 (2009) :

• Background Reference 03:

  Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)

• Background Reference 04:

  Yoon, H.G., et al. Mol. Cell 12 (3) :723-734 (2003)

• Other Product Names:

  Coronin-2A, IR10, WD repeat-containing protein 2, CORO2A, IR10, WDR2

• Tested Applications:

  WB

• Protein ID:

  28381354

• Physical Properties:

  Liquid