CORO2A Antibody

• Background :

  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants.

• NCBI Gene ID :

  7464

• Swiss Prot :

  Q92828

• Accession Number :

  Q92828

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CORO2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human CORO2A.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  60 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  CORO2A

• NCBI Official Name :

  Coronin-2A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Jin, Y., et al. Nat. Genet. 42 (7) :576-578 (2010)

• Background Reference 02 :

  Marshall, T.W., et al. J. Cell. Sci. 122 (PT 17), 3061-3069 (2009) :

• Background Reference 03 :

  Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)

• Background Reference 04 :

  Yoon, H.G., et al. Mol. Cell 12 (3) :723-734 (2003)

• Other Product Names :

  Coronin-2A, IR10, WD repeat-containing protein 2, CORO2A, IR10, WDR2

• Tested Applications :

  WB

• Protein ID :

  28381354

• Physical Properties :

  Liquid