HNRNPH2 Antibody

• Background:

  This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.

• NCBI Gene ID:

  3188

• Swiss Prot:

  P55795

• Accession Number:

  P55795

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HNRNPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human HNRNPH2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  49 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  HNRNPH2

• NCBI Official Name:

  Heterogeneous nuclear ribonucleoprotein H2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 03:

  Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28 (23) :7050-7065 (2008)

• Background Reference 04:

  Miyasaka, T., et al. Cancer Sci. 99 (4) :755-761 (2008)

• Other Product Names:

  Heterogeneous nuclear ribonucleoprotein H2, hnRNP H2, FTP-3, Heterogeneous nuclear ribonucleoprotein H', hnRNP H', Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, HNRNPH2, FTP3, HNRPH2

• Tested Applications:

  WB

• Protein ID:

  2500576

• Physical Properties:

  Liquid