JPH2 Antibody

• Background:

  Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

• NCBI Gene ID:

  57158

• Swiss Prot:

  Q9BR39

• Accession Number:

  Q9BR39

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  JPH2

• NCBI Official Name:

  Junctophilin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Woo, J.S., et al. Biochem. J. 427 (1) :125-134 (2010)

• Background Reference 03:

  Yamazaki, D., et al. Pharmacol. Ther. 121 (3) :265-272 (2009)

• Background Reference 04:

  Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42 (6) :1026-1035 (2007)

• Other Product Names:

  Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2

• Tested Applications:

  WB

• Protein ID:

  27805486

• Physical Properties:

  Liquid