Mertansine

• Description:

  Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) [1][2].

• Product Name Alternative:

  DM1; Maytansinoid DM1

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Payload; Microtubule/Tubulin

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Mertansine.html

• Purity:

  99.80

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCS)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

• Molecular Formula:

  C35H48ClN3O10S

• Molecular Weight:

  738.29

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.|[2]Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307 (2) :113-8.|[3]Zhong P, et al. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 2017 Jul 21;28 (29) :295103.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  Phase 2

• Isoform:

  Maytansinoids

• CAS Number:

  [139504-50-0]