RBM28 Antibody

• Background:

  The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP) complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  55131

• Swiss Prot:

  Q9NW13

• Accession Number:

  Q9NW13

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RBM28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the N-terminal region of human RBM28.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  86 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RBM28

• NCBI Official Name:

  RNA-binding protein 28

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Spiegel, R., et al. Eur. J. Endocrinol. 162 (6) :1021-1025 (2010)

• Background Reference 02:

  Nousbeck, J., et al. Am. J. Hum. Genet. 82 (5) :1114-1121 (2008)

• Background Reference 03:

  Damianov, A., et al. Biol. Chem. 387 (10-11), 1455-1460 (2006) :

• Background Reference 04:

  Andersen, J.S., et al. Nature 433 (7021) :77-83 (2005)

• Other Product Names:

  RNA-binding protein 28, RNA-binding motif protein 28, RBM28

• Tested Applications:

  WB

• Protein ID:

  55976611

• Physical Properties:

  Liquid