ASPH Antibody

• Background:

  This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF) -like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

• NCBI Gene ID:

  444

• Swiss Prot:

  Q12797

• Accession Number:

  Q12797

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ASPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human ASPH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  86 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ASPH

• NCBI Official Name:

  Aspartyl/asparaginyl beta-hydroxylase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xue, T., et al. Hybridoma (Larchmt) 28 (4) :251-257 (2009)

• Background Reference 02:

  Luu, M., et al. Hum. Pathol. 40 (5) :639-644 (2009)

• Background Reference 03:

  Finotti, A., et al. BMC Mol. Biol. 9, 110 (2008) :

• Background Reference 04:

  Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (33) :12130-12135 (2004)

• Other Product Names:

  Aspartyl/asparaginyl beta-hydroxylase, Aspartate beta-hydroxylase, ASP beta-hydroxylase, Peptide-aspartate beta-dioxygenase, ASPH, BAH

• Tested Applications:

  WB, IHC-P

• Protein ID:

  145559444

• Physical Properties:

  Liquid