ASPH Antibody

CAT: 0223-56-642Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-642Size:400 µL
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Background
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF) -like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
NCBI Gene ID
444
Swiss Prot
Q12797
Accession Number
Q12797
Host
Rabbit
Reactivity
Human
Immunogen
This ASPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human ASPH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Symbol
ASPH
NCBI Official Name
Aspartyl/asparaginyl beta-hydroxylase
NCBI Organism
Homo sapiens
Background Reference 01
Xue, T., et al. Hybridoma (Larchmt) 28 (4) :251-257 (2009)
Background Reference 02
Luu, M., et al. Hum. Pathol. 40 (5) :639-644 (2009)
Background Reference 03
Finotti, A., et al. BMC Mol. Biol. 9, 110 (2008) :
Background Reference 04
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (33) :12130-12135 (2004)
Other Product Names
Aspartyl/asparaginyl beta-hydroxylase, Aspartate beta-hydroxylase, ASP beta-hydroxylase, Peptide-aspartate beta-dioxygenase, ASPH, BAH
Tested Applications
WB, IHC-P
Protein ID
145559444
Physical Properties
Liquid

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