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GSTM5 Antibody

CAT: 0223-56-608Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-608Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
NCBI Gene ID
2949
Swiss Prot
P46439
Accession Number
P46439
Host
Rabbit
Reactivity
Human
Immunogen
This GSTM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human GSTM5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Symbol
GSTM5
NCBI Official Name
Glutathione S-transferase Mu 5
NCBI Organism
Homo sapiens
Background Reference 01
Wang, Y., et al. J. Hum. Genet. 55 (8) :490-494 (2010)
Background Reference 02
Yu, K.D., et al. Breast Cancer Res. Treat. 121 (2) :485-496 (2010)
Background Reference 03
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 04
Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19 (3) :811-821 (2010)
Other Product Names
Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5, GSTM5
Tested Applications
WB, IHC-P, Flow
Protein ID
67476963
Physical Properties
Liquid

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