GSTM5 Antibody

• Background:

  Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.

• NCBI Gene ID:

  2949

• Swiss Prot:

  P46439

• Accession Number:

  P46439

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GSTM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human GSTM5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GSTM5

• NCBI Official Name:

  Glutathione S-transferase Mu 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wang, Y., et al. J. Hum. Genet. 55 (8) :490-494 (2010)

• Background Reference 02:

  Yu, K.D., et al. Breast Cancer Res. Treat. 121 (2) :485-496 (2010)

• Background Reference 03:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 04:

  Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19 (3) :811-821 (2010)

• Other Product Names:

  Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5, GSTM5

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  67476963

• Physical Properties:

  Liquid