COX6B1 Antibody

• Background :

  Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.

• NCBI Gene ID :

  1340

• Swiss Prot :

  P14854

• Accession Number :

  P14854

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human COX6B1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  10 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  COX6B1

• NCBI Official Name :

  Cytochrome c oxidase subunit 6B1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Lazarou, M., et al. FEBS J. 276 (22) :6701-6713 (2009)

• Background Reference 02 :

  Massa, V., et al. Am. J. Hum. Genet. 82 (6) :1281-1289 (2008)

• Background Reference 03 :

  Sirchia, R., et al. Biol. Chem. 388 (5) :457-465 (2007)

• Background Reference 04 :

  Schmidt, T.R., et al. Gene 286 (1) :13-19 (2002)

• Other Product Names :

  Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1, COX6B1, COX6B

• Tested Applications :

  WB, IHC-P

• Protein ID :

  117115

• Physical Properties :

  Liquid