COX6B1 Antibody

CAT: 0223-56-356Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-356Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
NCBI Gene ID
1340
Swiss Prot
P14854
Accession Number
P14854
Host
Rabbit
Reactivity
Human
Immunogen
This COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human COX6B1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
10 kDa
Fragment
Rabbit Ig
Symbol
COX6B1
NCBI Official Name
Cytochrome c oxidase subunit 6B1
NCBI Organism
Homo sapiens
Background Reference 01
Lazarou, M., et al. FEBS J. 276 (22) :6701-6713 (2009)
Background Reference 02
Massa, V., et al. Am. J. Hum. Genet. 82 (6) :1281-1289 (2008)
Background Reference 03
Sirchia, R., et al. Biol. Chem. 388 (5) :457-465 (2007)
Background Reference 04
Schmidt, T.R., et al. Gene 286 (1) :13-19 (2002)
Other Product Names
Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1, COX6B1, COX6B
Tested Applications
WB, IHC-P
Protein ID
117115
Physical Properties
Liquid

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