SNX13 Antibody

• Background:

  This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha (s), accelerates its GTP hydrolysis, and attenuates G alpha (s) -mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.

• NCBI Gene ID:

  23161

• Swiss Prot:

  Q9Y5W8

• Accession Number:

  Q9Y5W8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SNX13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-807 amino acids from the C-terminal region of human SNX13.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  112 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SNX13

• NCBI Official Name:

  Sorting nexin-13

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J. Phd, et al. Mol. Med. (2010) In press :

• Background Reference 02:

  Hillman, R.T., et al. Genome Biol. (2), R8 (2004) :

• Background Reference 03:

  Worby, C.A., et al. Nat. Rev. Mol. Cell Biol. 3 (12) :919-931 (2002)

• Background Reference 04:

  Kosan, C., et al. Cytogenet. Genome Res. 97 (3-4), 167-170 (2002) :

• Other Product Names:

  Sorting nexin-13, RGS domain- and PHOX domain-containing protein, RGS-PX1, SNX13, KIAA0713

• Tested Applications:

  WB

• Protein ID:

  24418867

• Physical Properties:

  Liquid