IGF2 Antibody

• Background:

  This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  3481

• Swiss Prot:

  P01344

• Accession Number:

  P01344

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This IGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the Central region of human IGF2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  20 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IGF2

• NCBI Official Name:

  Insulin-like growth factor II

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Adkins, R.M., et al. Pediatr. Res. 68 (5) :429-434 (2010)

• Background Reference 02:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 03:

  Li, J., et al. Mol. Biol. Rep. (2010) In press :

• Background Reference 04:

  Hsieh, Y.Y., et al. Anticancer Res. 30 (6) :2203-2208 (2010)

• Other Product Names:

  Insulin-like growth factor II, IGF-II, Somatomedin-A, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  124255

• Physical Properties:

  Liquid