ETFA Antibody

• Background:

  ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  2108

• Swiss Prot:

  P13804

• Accession Number:

  P13804

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ETFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the C-terminal region of human ETFA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  35 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ETFA

• NCBI Official Name:

  Electron transfer flavoprotein subunit alpha, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ohkuma, A., et al. Muscle Nerve 39 (3) :333-342 (2009) Chiong, M.A., et al. Mol. Genet. Metab. 92 (1-2), 109-114 (2007) Olsen, J.V., et al. Cell 127 (3) :635-648 (2006) Olsen, J.V., et al. Cell 127 (3) :635-648 (2006) Schiff, M., et al. Mol. Genet. Metab. 88 (2) :153-158 (2006)

• Other Product Names:

  Electron transfer flavoprotein subunit alpha, mitochondrial, Alpha-ETF, ETFA

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  119636

• Physical Properties:

  Liquid