IGF-BP7 Antibody (biotin)

• Background:

  IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGF-BP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGF-BP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin.

• NCBI Gene ID:

  3490

• Swiss Prot:

  Q16270

• Accession Number:

  Q16270

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIGF-BP7. Human IGF-BP7 specific antibody was purified by affinity chromatography and then biotinylated.

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Primary Antibodies, Antibody Pairs

• Field of Research:

  Other

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  IGF-BP7 antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

• Symbol:

  IGFBP7

• NCBI Official Name:

  Insulin-like growth factor binding protein 7

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  AGM, PSF, TAF, FSTL2, IBP-7, MAC25, IGFBP-7, RAMSVPS, IGFBP-7v, IGFBPRP1, Insulin-like growth factor-binding protein 7, IGFBP-rP1

• Tested Applications:

  ELISA, WB

• Protein ID:

  23396609

• Physical Properties:

  Lyophilized