Nanog Antibody

• Background:

  Nanog is a newly identified homeodomain-bearing transcriptional factor. Nanog expression is specific to early embryos and pluripotential stem cells including mouse and human embryonic stem (ES) and embryonic germ (EG) cells. It is a key molecule involved in the signaling pathway for maintaining the capacity for self-renewal and pluripotency, bypassing regulation by the STAT3 pathway. Nanog mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Nanog-deficient ES cells lose pluripotency and differentiate into extraembryonic endoderm lineage. Thus it is one of the molecular markers suitable for recognizing the undifferentiated state of stem cells in the mouse and human.

• NCBI Gene ID:

  79923

• Swiss Prot:

  Q9H9S0

• Accession Number:

  Q9H9S0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hNanog. Human Nanog specific antibody was purified by affinity chromatography employing immobilized hNanog matrix.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Antibody Pairs

• Field of Research:

  Cancer

• Purification:

  Nanog antibody was purified by affinity chromatography employing immobilized Nanog matrix.

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Nanog antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

• Symbol:

  NANOG

• NCBI Official Name:

  Nanog homeobox

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog

• Tested Applications:

  ELISA, WB

• Protein ID:

  118573073

• Physical Properties:

  Lyophilized