TRAIL-R2 Antibody [HS201] (biotin)

• Background:

  TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

• NCBI Gene ID:

  8795

• Swiss Prot:

  O14763

• Accession Number:

  2338419

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human TRAIL-R2 (DR5) .

• Clonality:

  Monoclonal

• Clone:

  HS201

• Conjugation:

  Biotin

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Apoptosis, Cancer, Immunology

• Purification:

  >95% (SDS-PAGE)

• Concentration:

  0.5 mg/ml

• Buffer:

  Liquid. In PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1

• Specificity:

  Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

• Applications Notes:

  Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution) . Immunohistochemistry: (paraffin sections, 15ug/ml) .

• Symbol:

  TNFRSF10B

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 10b

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262

• Tested Applications:

  Flow, Functional Assays, ICC, IHC, IP

• Protein ID:

  AF012535

• Physical Properties:

  Liquid