LAG-3 Antibody [17B4]

• Background:

  Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

• NCBI Gene ID:

  3902

• Swiss Prot:

  P18627

• Accession Number:

  251757512

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

• Clonality:

  Monoclonal

• Clone:

  17B4

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology, Innate Immunity

• Purification:

  >95% (SDS-PAGE)

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1

• Specificity:

  Recognizes human LAG-3.

• Applications Notes:

  Immunohistochemistry: (EM) . Immunoprecipitation: (1-2ug/ml) . Western Blot: (1-5ug/ml) . Optimal conditions must be determined individually for each application.

• Symbol:

  LAG3

• NCBI Official Name:

  Lymphocyte activating 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Lymphocyte Activation Gene-3; FDC Protein; CD223

• Tested Applications:

  Functional Assays, ICC, IHC, IP, WB

• Protein ID:

  P18627

• Physical Properties:

  Liquid