NUDT15 Antibody

• Background:

  Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity) . May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.

• NCBI Gene ID:

  55270

• Swiss Prot:

  Q9NV35

• Accession Number:

  Q9NV35

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NUDT15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the C-terminal region of human NUDT15.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NUDT15

• NCBI Official Name:

  Probable 8-oxo-dGTP diphosphatase NUDT15

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hori, M., et al. Free Radic. Biol. Med. 48 (9) :1197-1201 (2010) Yu, Y., et al. J. Biol. Chem. 284 (29) :19310-19320 (2009) Dunham, A., et al. Nature 428 (6982) :522-528 (2004) Cai, J.P., et al. Biochem. Biophys. Res. Commun. 305 (4) :1073-1077 (2003)

• Other Product Names:

  Probable 8-oxo-dGTP diphosphatase NUDT15, 8-oxo-dGTPase NUDT15,8-dihydro-8-oxoguanine-triphosphatase NUDT15, MutT homolog 2, MTH2, Nucleoside diphosphate-linked moiety X motif 15, Nudix motif 15, NUDT15, MTH2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  68565944

• Physical Properties:

  Liquid