ITIH5 Antibody

• Background:

  This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  80760

• Swiss Prot:

  Q86UX2

• Accession Number:

  Q86UX2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ITIH5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 578-606 amino acids from the C-terminal region of human ITIH5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  105 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ITIH5

• NCBI Official Name:

  Inter-alpha-trypsin inhibitor heavy chain H5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Pita, J.M., et al. Br. J. Cancer 101 (10) :1782-1791 (2009)

• Background Reference 02:

  Veeck, J., et al. Pathologe 29 SUPPL 2, 338-346 (2008) :

• Background Reference 03:

  Veeck, J., et al. Oncogene 27 (6) :865-876 (2008)

• Background Reference 04:

  Hamm, A., et al. BMC Cancer 8, 25 (2008) :

• Other Product Names:

  Inter-alpha-trypsin inhibitor heavy chain H5, ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5, ITIH5, KIAA1953

• Tested Applications:

  WB, IHC-P

• Protein ID:

  187609608

• Physical Properties:

  Liquid