B4GALT6 Antibody

• Background:

  This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.

• NCBI Gene ID:

  9331

• Swiss Prot:

  Q9UBX8

• Accession Number:

  Q9UBX8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This B4GALT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-346 amino acids from the C-terminal region of human B4GALT6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  B4GALT6

• NCBI Official Name:

  Beta-1,4-galactosyltransferase 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (22) :9004-9009 (2009) Gevaert, K., et al. Nat. Biotechnol. 21 (5) :566-569 (2003) Fan, Y., et al. DNA Seq. 13 (1) :1-8 (2002) Amado, M., et al. Biochim. Biophys. Acta 1473 (1) :35-53 (1999) Takizawa, M., et al. Biochim. Biophys. Acta 1438 (2) :301-304 (1999)

• Other Product Names:

  Beta-1,4-galactosyltransferase 6, Beta-1,4-GalTase 6, Beta4Gal-T6, b4Gal-T6, 241-, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6, Glucosylceramide beta-1,4-galactosyltransferase, Lactosylceramide synthase, LacCer synthase, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, B4GALT6

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  13123991

• Physical Properties:

  Liquid