FSH Receptor Antibody [FSHR/1400]

• Background:

  Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG) . In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

• NCBI Gene ID:

  2492

• Swiss Prot:

  P23945

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A human recombinant protein was used as the immunogen for this FSHR antibody.

• Clonality:

  Monoclonal

• Clone:

  FSHR/1400

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  FSHR

• NCBI Official Name:

  Follicle stimulating hormone receptor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FSHR, Follitropin receptor, FSHRO, Ovarian dysgenesis 1, FSH receptor, FSH-R, LGR1, ODG1

• Tested Applications:

  Flow, IHC, IF

• Physical Properties:

  Liquid