PCDHGC3 Antibody

• Background:

  This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

• NCBI Gene ID:

  5098

• Swiss Prot:

  Q9UN70

• Accession Number:

  Q9UN70

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCDHGC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 511-539 amino acids from the Central region of human PCDHGC3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PCDHGC3

• NCBI Official Name:

  Protocadherin gamma-C3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Reiss, K., et al. J. Biol. Chem. 281 (31) :21735-21744 (2006)

• Background Reference 02:

  Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)

• Background Reference 03:

  Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)

• Background Reference 04:

  Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000)

• Other Product Names:

  Protocadherin gamma-C3, PCDH-gamma-C3, Protocadherin-2, Protocadherin-43, PC-43, PCDHGC3, PCDH2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  37999813

• Physical Properties:

  Liquid