CCL21 Antibody

• Background:

  This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19) . [provided by RefSeq].

• NCBI Gene ID:

  6366

• Swiss Prot:

  O00585

• Accession Number:

  O00585

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CCL21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the Central region of human CCL21.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  15 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CCL21

• NCBI Official Name:

  C-C motif chemokine 21

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rey-Gallardo, A., et al. Glycobiology 20 (9) :1139-1146 (2010) Cuesta-Mateos, C., et al. Exp. Hematol. 38 (9) :756-764 (2010) Sundqvist, J., et al. Fertil. Steril. (2010) In pressPlant, D., et al. Ann. Rheum. Dis. 69 (8) :1548-1553 (2010) Farragher, T.M., et al. Arthritis Care Res (Hoboken) 62 (5) :676-682 (2010)

• Other Product Names:

  C-C motif chemokine 21, 6Ckine, Beta-chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21, CCL21, SCYA21

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid