UGT1A1 Antibody

UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

54658

P22309

NP_000454

Human

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UGT1A1.

Unconjugated

Primary Antibodies

Membrane, Cancer, Signal Transduction

Antibody is purified by protein A chromatography method.

Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store UGT1A1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

57 kDa

UGT1A1 antibody can be used for detection of UGT1A1 by ELISA at 1:1562500. UGT1A1 antibody can be used for detection of UGT1A1 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1

Homo sapiens

Wasmuth, H.E., (2006) Hepatology 43 (4), 738-741.

UGT1A1, GNT1, HUG-BR1, UDPGT, UGT1, UGT1A, BILIQTL1, UDPGT 1-1

ELISA, WB

8850236