RGS18 Antibody

RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

64407

Q9NS28

NP_570138

Human, Dog

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RGS18.

Unconjugated

Primary Antibodies

Signal Transduction

Antibody is purified by protein A chromatography method.

Cat. No. XBL-10426 - Fetal Thymus Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store RGS18 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

26 kDa

RGS18 antibody can be used for detection of RGS18 by ELISA at 1:62500. RGS18 antibody can be used for detection of RGS18 by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

RGS18

Regulator of G-protein signaling 18

Homo sapiens

Aldenhoven, J., Cytogenet. Genome Res. 112 (3-4), 341F (2006) .

RGS18, RP11-142L4.1, RGS13

ELISA, WB

18640750