MTA1 Antibody

• Background :

  MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. MTA1 was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

• NCBI Gene ID :

  9112

• Swiss Prot :

  Q13330-2

• Accession Number :

  AAN01613

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat, Dog

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MTA1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Transcription, Cancer, Signal Transduction

• Purification :

  Antibody is purified by protein A chromatography method.

• Positive Control :

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MTA1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  47 kDa, 81 kDa

• Applications Notes :

  MTA1 antibody can be used for detection of MTA1 by ELISA at 1:62500. MTA1 antibody can be used for detection of MTA1 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  MTA1

• NCBI Official Name :

  Metastasis associated 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Kumar, R., et al., (2002) Nature 418 (6898), 654-658.

• Other Product Names :

  MTA1

• Tested Applications :

  ELISA, WB

• Protein ID :

  22550298

• Physical Properties :

  Liquid