FOXP2 Antibody

• Background:

  FOXP2 is an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.

• NCBI Gene ID:

  93986

• Swiss Prot:

  O15409

• Accession Number:

  NP_055306

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Dog

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FOXP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store FOXP2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  80 kDa, 83 kDa

• Applications Notes:

  FOXP2 antibody can be used for detection of FOXP2 by ELISA at 1:62500. FOXP2 antibody can be used for detection of FOXP2 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  FOXP2

• NCBI Official Name:

  Forkhead box P2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sanjuan, J., et al., (2006) Psychiatr. Genet. 16 (2), 67-72.

• Other Product Names:

  FOXP2, SPCH1, CAGH44, TNRC10

• Tested Applications:

  ELISA, WB

• Protein ID:

  17017963

• Physical Properties:

  Liquid