TMEM173 Antibody

• Background:

  TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) . TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

• NCBI Gene ID:

  340061

• Swiss Prot:

  Q86WV6

• Accession Number:

  NP_938023

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TMEM173.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TMEM173 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  42 kDa

• Applications Notes:

  TMEM173 antibody can be used for detection of TMEM173 by ELISA at 1:62500. TMEM173 antibody can be used for detection of TMEM173 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  TMEM173

• NCBI Official Name:

  Transmembrane protein 173

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gerhard, D.S., Genome Res. 14 (10B), 2121-2127 (2004) .

• Other Product Names:

  TMEM173, FLJ38577, ERIS, MITA, MPYS, NET23, STING

• Tested Applications:

  ELISA, WB

• Protein ID:

  38093659

• Physical Properties:

  Liquid