HOXA5 Antibody

• Background:

  In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA5 is a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of the gene encoding HOXA5 may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

• NCBI Gene ID:

  3202

• Swiss Prot:

  A2D5Y4

• Accession Number:

  NP_061975

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Drosophila

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HOXA5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1309 - Human Placenta Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store HOXA5 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  30 kDa

• Applications Notes:

  HOXA5 antibody can be used for detection of HOXA5 by ELISA at 1:312500. HOXA5 antibody can be used for detection of HOXA5 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  HOXA5

• NCBI Official Name:

  Homeobox A5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, Y. (2008) Blood 111 (3), 1217-1226.

• Other Product Names:

  HOXA5, HOX1, HOX1.3, HOX1C, MGC9376

• Tested Applications:

  ELISA, WB

• Protein ID:

  24497517

• Physical Properties:

  Liquid