KIF2A Antibody

• Background:

  KIF2A belongs to the kinesin-like protein family, MCAK/KIF2 subfamily. It contains 1 kinesin-motor domain. KIF2A plus end-directed microtubule-dependent motor required for normal brain development. It may regulate microtubule dynamics during axonal growth. KIF2A is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerization activity. Hela cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.

• NCBI Gene ID:

  3796

• Swiss Prot:

  O00139

• Accession Number:

  NP_004511

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KIF2A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KIF2A antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  80 kDa

• Applications Notes:

  KIF2A antibody can be used for detection of KIF2A by ELISA at 1:62500. KIF2A antibody can be used for detection of KIF2A by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  KIF2A

• NCBI Official Name:

  Kinesin heavy chain member 2A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jang, C.Y., (2008) J. Cell Biol. 181 (2), 255-267.

• Other Product Names:

  KIF2A, HK2, KIF2, CDCBM3

• Tested Applications:

  ELISA, WB

• Protein ID:

  148612877

• Physical Properties:

  Liquid