EXOC2 Antibody

• Background :

  The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  55770

• Swiss Prot :

  Q96KP1

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EXOC2 (NP_060773.3) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  A-549

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 108kDa

• Fragment :

  IgG

• Symbol :

  EXOC2

• Positive Control 2 :

  MCF7

• Positive Control 3 :

  HeLa

• Positive Control 4 :

  Mouse lung

• Positive Control 5 :

  Rat brain

• NCBI Official Name :

  Exocyst complex component 2

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  EXOC2, Exocyst complex component 2, SEC5L1, Sec5p, Exocyst complex component Sec5, SEC5, SEC5-like 1, SEC5-like 1 (S. cerevisiae)

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid