IDH2 Antibody

• Background :

  Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. The protein encoded by this gene is the NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  3418

• Swiss Prot :

  P48735

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 193-452 of human IDH2 (NP_002159.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  HL-60

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 51kDa

• Fragment :

  IgG

• Symbol :

  IDH2

• Positive Control 2 :

  MCF-7

• Positive Control 3 :

  Jurkat

• Positive Control 4 :

  HepG2

• Positive Control 5 :

  U-87MG

• Positive Control 6 :

  Mouse kidney

• NCBI Official Name :

  Isocitrate dehydrogenase 2 (NADP+), mitochondrial

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  IDH2 Antibody: IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDHICD-M, IDH

• Tested Applications :

  WB, IHC, IF, IP, ChIP

• Physical Properties :

  Liquid