CAPNS1 Antibody

• Background :

  This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  826

• Swiss Prot :

  P04632

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human CAPNS1 (NP_001740.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology, Neuroscience, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  BT-474

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 28kDa

• Fragment :

  IgG

• Symbol :

  CAPNS1

• Positive Control 2 :

  U-251MG

• Positive Control 3 :

  SKOV3

• Positive Control 4 :

  Mouse lung

• Positive Control 5 :

  Mouse heart

• Positive Control 6 :

  Mouse spleen

• NCBI Official Name :

  Calpain small subunit 1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, calpain small subunit 1, CANP small subunit, calcium-activated neutral proteinase small subunit, calcium-dependent protease small subunit 1, calcium-dependent protease, small subunit, calpain 4, small subunit (30K), calpain regulatory subunit, calpain, small polypeptide, epididymis secretory sperm binding protein

• Tested Applications :

  WB, IHC, IF

• Physical Properties :

  Liquid