Ansuvimab - Research Grade Biosimilar

• Background:

  Responsible for binding to the receptor (s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into dendritic cells (DCs) and endothelial cells . Binding to the macrophage specific lectin CLEC10A also seem to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection. Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L presumably induces a conformational change of GP2, allowing its binding to the host entry receptor NPC1 and unmasking its fusion peptide to initiate membranes fusion.

• NCBI Gene ID:

  911829

• Swiss Prot:

  Q05320

• Accession Number:

  Q05320

• Immunogen:

  Humanized / GP1 surface protein of Ebolavirus

• Clonality:

  Recombinant Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Biosimilars

• Source:

  CHO cells

• Field of Research:

  Other

• Purification:

  >95%

• Concentration:

  Batch dependent

• Purity:

  >95%

• Buffer:

  PBS buffer pH 7.5

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4°C short term (1-2 weeks) . Store at -20 °C 12 months. Store at -80°C long term.

• Fragment:

  IgG1

• Symbol:

  GP

• NCBI Official Name:

  Second secreted glycoprotein; small secreted glycoprotein; spike glycoprotein

• NCBI Organism:

  Zaire ebolavirus