Certolizumab - Research Grade Biosimilar

• Background:

  Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

• NCBI Gene ID:

  7124

• Swiss Prot:

  P01375

• Accession Number:

  P01375

• Clonality:

  Recombinant Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Biosimilars

• Source:

  CHO cells

• Field of Research:

  Other

• Purification:

  >95%

• Concentration:

  Batch dependent

• Purity:

  >95%

• Buffer:

  PBS buffer pH 7.5

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4°C short term (1-2 weeks) . Store at -20 °C 12 months. Store at -80°C long term.

• Fragment:

  Fab-IgG1

• Symbol:

  TNF

• NCBI Official Name:

  Tumor necrosis factor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha