NOTCH3 Antibody

• Background :

  This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

• NCBI Gene ID :

  4854

• Swiss Prot :

  Q9UM47

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  A synthetic peptide of human NOTCH3

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Neuroscience, Signal Transduction, Stem Cell, Transcription

• Purification :

  Affinity purification

• Positive Control :

  293T

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 90kDa/280kDa

• Fragment :

  IgG

• Symbol :

  NOTCH3

• NCBI Official Name :

  Notch 3

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  NOTCH3, Notch homolog 3 (Drosophila), HGNC:7883, CADASIL, CASIL, Notch (Drosophila) homolog 3, Notch homolog 3, IMF2

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid