APBB1 Antibody

• Background:

  The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

• NCBI Gene ID:

  322

• Swiss Prot:

  O00213

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  Raji

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 63kDa

• Fragment:

  IgG

• Symbol:

  APBB1

• Positive Control 2:

  Lovo

• Positive Control 3:

  BT-474

• Positive Control 4:

  A-549

• Positive Control 5:

  Mouse brain

• Positive Control 6:

  Mouse heart

• NCBI Official Name:

  Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, adaptor protein FE65a2, amyloid beta A4 precursor protein-binding, member 1, stat-like protein

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid