APOB Antibody

• Background :

  This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

• NCBI Gene ID :

  338

• Swiss Prot :

  P04114

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 28-330 of human APOB (NP_000375.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  LO2

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 110kDa

• Fragment :

  IgG

• Symbol :

  APOB

• Positive Control 2 :

  HepG2

• Positive Control 3 :

  HL-60

• Positive Control 4 :

  Mouse liver

• Positive Control 5 :

  Mouse kidney

• Positive Control 6 :

  Rat liver

• NCBI Official Name :

  Apolipoprotein B

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  APOB, apolipoprotein B (including Ag (x) antigen), FLDB, apoB-100, apoB-48, apolipoprotein B, apolipoprotein B48, LDLCQ4

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid