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Caspase 1 Antibody

CAT: 0223-13-340Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-13-340Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
NCBI Gene ID
834
Swiss Prot
P29466
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human Caspase 1 (NP_150635.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction, Inflammasomes
Purification
Affinity purification
Positive Control
THP-1
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 30kDa/48kDa
Fragment
IgG
Symbol
CASP1
Positive Control 2
HeLa
Positive Control 3
Mouse lung
NCBI Official Name
Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
NCBI Organism
Homo sapiens
Other Product Names
Caspase-1 Antibody: ICE, P45, IL1BC, IL1BCE, Caspase-1, Interleukin-1 beta convertase, CASP-1
Tested Applications
WB, IHC, IF, IP
Physical Properties
Liquid

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