SARS-CoV-2 (COVID-19) ORF8 Antibody

• Background:

  Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF8 may play a role in modulating host immune response (Probable) . May play a role in blocking host IL17 cytokine by its interaction with host IL17RA (3) .

• NCBI Gene ID:

  43740577

• Swiss Prot:

  P0DTC8

• Accession Number:

  P0DTC8

• Host:

  Rabbit

• Reactivity:

  Virus

• Immunogen:

  9287

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  SARS-CoV-2 (COVID-19) ORF8 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Buffer:

  SARS-CoV-2 (COVID-19) ORF8 antibody is supplied in PBS containing 0.02% sodium azide.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV-2 (COVID-19) ORF8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  14kD

• Fragment:

  IgG

• Specificity:

  ORF8 Antibody is predicted to not cross-react with other coronavirus family members.

• Symbol:

  ORF8

• NCBI Official Name:

  ORF8 protein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Gorbalenya. bioRxiv: 2020.

• Background Reference 02:

  Hui et al. Int J Infect Dis. 2020;91:264-266.

• Background Reference 03:

  Chan et al. Lancet. 2020; 395:514-523.

• Other Product Names:

  ORF8 protein, ns8, ORF8, Non-structural protein 8

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  1835921949

• Physical Properties:

  Liquid