SARS-CoV-2 (COVID-19) ORF6 Antibody

• Background:

  Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. ORF6 disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby it prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (3) .

• NCBI Gene ID:

  43740572

• Swiss Prot:

  P0DTC6

• Accession Number:

  QKU37157.1

• Host:

  Rabbit

• Reactivity:

  Virus

• Immunogen:

  9189

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  SARS-CoV-2 (COVID-19) ORF6 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Homology:

  Predicted reactivity based on immunogen sequence: SARS-CoV ORF6 protein: (53%)

• Buffer:

  SARS-CoV-2 (COVID-19) ORF6 Antibody is supplied in PBS containing 0.02% sodium azide.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV-2 (COVID-19) ORF6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Applications Notes:

  Antibody validated: SARS-CoV-2 (COVID-19) ORF6 antibody can detect 2 ng of free peptide at 1 μ g/mL in ELISA.

• Symbol:

  ORF6

• NCBI Official Name:

  ORF6 protein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Gorbalenya. bioRxiv: 2020.

• Background Reference 02:

  Hui et al. Int J Infect Dis. 2020;91:264-266.

• Background Reference 03:

  Frieman et. al. J.Virol. 2007;81:9812-9824

• Other Product Names:

  Accessory protein 6, Non-structural protein 6, ns6, Protein X3

• Tested Applications:

  ELISA

• Protein ID:

  1858802908

• Physical Properties:

  Liquid