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SLC38A4 Antibody

CAT: 0223-8343-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8343-01Size:0.02 mg
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Background
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids (1,2) . The transport of cationic amino acids by SLC38A4 is sodium and pH independent, while the transport of neutral amino acids is sodium and pH dependent (2) . Recent evidence suggests that SLC38A4 functions as a regulator of protein synthesis downstream of the hepatocyte nuclear factor 4a during liver development (3) . It has also been suggested that SLC38A4 has ATPase activity and is critically involved in the maintenance of mitochondrial homeostasis and cell survival (4) .
NCBI Gene ID
55089
Swiss Prot
Q969I6
Accession Number
NP_060488
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Homeostasis
Purification
SLC38A4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (71%)
Buffer
SLC38A4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLC38A4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SLC38A4 antibody is human and mouse reactive. SLC38A4 will not cross-react with other members of the SLC38 protein family.
Symbol
SLC38A4
NCBI Official Name
Solute carrier family 38, member 4
NCBI Organism
Homo sapiens
Background Reference 01
Sugawara M, Nakanishi T, Fei YJ, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal system. Biochim. Biophys. Acta 2000; 1509:7-13.
Background Reference 02
Hatanaka T, Huang W, Ling R, et al. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim. Biophys. Acta 2001 1510:10-7.
Background Reference 03
Kondou H, Kawai M, Tachikawa K, et al. Sodium-coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development. Hepatol. Res. 2013; 43:1211-23.
Background Reference 04
Yang X, Yang J, Li L, et al. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB J. 2014; 28:4821-34.
Other Product Names
Solute carrier family 38 member 4, sodium-coupled neutral amino acid transporter 4, SNAT4, protein associated with ABC transporters, PAAT, ATA3, NAT3
Tested Applications
ELISA, WB, IHC-P
Protein ID
18482385
Physical Properties
Liquid