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TRPC3 Antibody

CAT: 0223-8269-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8269-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
NCBI Gene ID
7222
Swiss Prot
Q13507
Accession Number
NP_001124170
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Neuroscience
Purification
TRPC3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1362 - Human Cerebellum Tissue Lysate
Concentration
1 mg/mL
Buffer
TRPC3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TRPC3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TRPC3 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect the three largest isoforms. TRPC3 antibody is predicted to not cross-react with TRPC6.
Symbol
TRPC3
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Transient receptor potential cation channel, subfamily C, member 3
NCBI Organism
Homo sapiens
Background Reference 01
Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.
Background Reference 02
Trebak M, Vazquez G, Bird GSJ, et al. The TRPC3/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61.
Background Reference 03
Zitt C, Obukhov AG, Strubing C, et al. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J. Cell. Biol. 1997; 1333-41.
Background Reference 04
Dietrich A, Kalwa H, Rost BR, et al. The diacylglycerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005; 451:72-80.
Other Product Names
TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3
Tested Applications
ELISA, WB, IHC-P
Protein ID
194733735
Physical Properties
Liquid

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