ARID1A Antibody

• Background:

  The ARID1A protein is a member of the SWI/SNF family, whose members are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. ARID1A is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin (1) . It possesses a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. The C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that ARID1A confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions (2) .

• NCBI Gene ID:

  8289

• Swiss Prot:

  O14497

• Accession Number:

  NP_006006

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis, Signal Transduction

• Purification:

  ARID1A antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1220 - SK-N-SH Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  ARID1A antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ARID1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  ARID1A antibody is human, mouse and rat reactive. Multiple isoforms of ARID1A protein are known to exist.

• Symbol:

  ARID1A

• NCBI Official Name:

  AT rich interactive domain 1A (SWI-like)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martens JA and Winston F. Recent advances in understanding chromatin remodeling by Swi/Snf complexes. Curr. Opin. Genet. Dev. 2003; 13:136-42.

• Background Reference 02:

  Nie Z, Xue Y, Yang D, et al. A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol. Cell. Biol. 2000; 20:8879-88.

• Other Product Names:

  AT rich interactive domain 1A (SWI-like), RP1-50O24.1, B120, BAF250, BAF250a, BM029, C1orf4, ELD, hELD, MRD14, OSA1, hOSA1, P270, SMARCF1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  21264565

• Physical Properties:

  Liquid