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SLC29A1 Antibody

CAT: 0223-8125-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8125-01Size:0.02 mg
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Background
SLC29A1 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2) . SLC29A1 is a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium (3) . As a nucleoside transporter, SLC29A1 plays an important role in the uptake of nucleoside-based anti-cancer drugs; polymorphisms of point mutations in the gene encoding this protein may affect the efficacy of these drugs (4) .
NCBI Gene ID
2030
Swiss Prot
Q99808
Accession Number
NP_004946
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Homeostasis
Purification
SLC29A1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1316 - Human Ovary Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (81%), Mouse: (75%)
Buffer
SLC29A1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLC29A1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SLC29A1 antibody is human specific. SLC29A1 antibody is predicted to not cross-react with other SLC29 proteins.
Symbol
SLC29A1
Positive Control 2
Cat. No. 11-201 - Human Ovary Tissue Slide
NCBI Official Name
Solute carrier family 29 (equilibrative nucleoside transporter), member 1
NCBI Organism
Homo sapiens
Background Reference 01
Griffiths M, Beaumont N, Yao SY, et al. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat. Med. 1997; 3:89-93.
Background Reference 02
Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.
Background Reference 03
Mangravite LM, Xiao G, and Giacomini KM. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am. J. Physiol. Renal Physiol. 284:F902-10.
Background Reference 04
Zimmerman EI, Huang M, Leisewitz AV, et al. Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells. FEBS Lett. 2009; 583:425-9.
Other Product Names
Solute carrier family 29 member 1, Equilibrative nucleoside transporter 1, ENT1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4826716
Physical Properties
Liquid

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