Products for Research Use Only

MYH8 Antibody

CAT: 0223-8081-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8081-01Size:0.02 mg
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Background
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1) . MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal) is a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction (2,3) . This gene is predominantly expressed in fetal skeletal muscle. MYH8 is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations (3) . A mutation in this gene results in trismus-pseudocamptodactyly syndrome (4) .
NCBI Gene ID
4626
Swiss Prot
P13535
Accession Number
NP_002463
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
MYH8 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Horse: (95%), Rabbit: (95%), Pig: (89%), Bovine: (89%), Chicken: (89%)
Buffer
MYH8 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MYH8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
MYH8 antibody is human, mouse and rat reactive. MYH8 antibody is predicted to not cross-react with other members of the myosin heavy chain family.
Symbol
MYH8
NCBI Official Name
Myosin, heavy chain 8, skeletal muscle, perinatal
NCBI Organism
Homo sapiens
Background Reference 01
Yu H, Waddell JN, Kuang S, et al. Park7 expression influences myotube size and myosin expression in muscle. PLoS One 2014; 9:e92030.
Background Reference 02
Feghali R and Leinwand LA. Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain. J. Cell Biol. 1989; 108:1791-7.
Background Reference 03
Jullian EH, Kelly AM, Pompidou AJ, et al. Characterization of a human perinatal myosin heavy-chain transcript. Eur. J. Biochem. 1995; 230:1001-6.
Background Reference 04
Minzer-Conzetti K, Wu E, Vargervik K, et al. Phenotypic variation in trismus-pseudocamptodactyly syndrome caused by a recurrent MYH8 mutation. Clin. Dysmorphol. 2008; 17:1-4.
Other Product Names
Myosin heavy chain 8, Myosin-8, Myosin heavy chain skeletal muscle perinatal, MyHC-perinatal, MyHC-peri, MyHC-pn, gtMHC-F
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
153945790
Physical Properties
Liquid